Endometrial receptivity revisited: endometrial transcriptome adjusted for tissue cellular heterogeneity
نویسندگان
چکیده
منابع مشابه
Molecular and cellular aspects of endometrial receptivity.
Endocrine and paracrine controls regulate the endometrium during the luteal phase of the cycle to permit implantation. Part of this differentiation process is the production of a specific secretion which fills the intrauterine cavity and glandular lumen. Its molecular composition originates from the gland secretion, from transudations from stroma, from the endometrial blood vessels, and last, b...
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However, the notion of receptivity as a static state in which the tissue is poised, frozen in time, awaiting the arrival of an adequately developed embryo, is naïve. An integrative definition of receptivity must embrace communication between maternal and embryonic tissues. At receptivity, the endometrium has reached a point at which negotiation can begin that may or may not lead to successful i...
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STUDY QUESTION How can we study the full transcriptome of endometrial stromal and epithelial cells at the single-cell level? SUMMARY ANSWER By compiling and developing novel analytical tools for biopsy, tissue cryopreservation and disaggregation, single-cell sorting, library preparation, RNA sequencing (RNA-seq) and statistical data analysis. WHAT IS KNOWN ALREADY Although single-cell trans...
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The cell biological basis of endometrial receptivity and trophoblast invasiveness, the two preconditions for implantation ("implantation windowtl), still remains enigmatic. Recently, however, the application of modern concepts of cell biology and developmental biology concentrating on celladhesion and cell polarity seems to open promising new views of these phenomena. At implantation initiation...
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Lee CKF Department of Obstetrics and Gynecology, Faculty of Medicine, The university of Hong Kong, China Email: [email protected]
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ژورنال
عنوان ژورنال: Human Reproduction
سال: 2018
ISSN: 0268-1161,1460-2350
DOI: 10.1093/humrep/dey301